From: Peter Thiel and Reid Hoffman
You can revolutionize an industry even if you know nothing about it. You have to be able to learn about it very quickly then try to solve an existing problem with some new technology.
To do that you need people who can learn quickly. Unfortunately, experience makes people think that know everything and that makes them no good.
NOTE: I found this suprising. They said that before they started Paypal they knew nothing of the financial services industry and had to learn it from scratch.